ALPACA is a single nucleotide variant caller for next-generation sequencing data, providing intuitive control over the false discovery rate with generic sample filtering scenarios, leveraging OpenCL on CPU, GPU or any coprocessor to speed up calculations and an using HDF5 based persistent storage for iterative refinement of analyses within seconds. Often, variant calling entails filtering different samples against each other, e.g. disease samples vs. healthy samples, tumor vs. normal or children vs. parents.
Source: Tech